Proteins/UNIPROT:Q8WXH2

JPH3

ProteinUNIPROT:Q8WXH2

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.

Function from UniProtKB (Q8WXH2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

Huntington disease-like 2 has a germline basis in JPH3DiseaseGenCC HGNC:14203|MONDO:0011671Inferred only
neurodevelopmental disorder has a germline basis in JPH3DiseaseGenCC HGNC:14203|MONDO:0700092Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: JPH3 · Sources: gene ontology, Hetionet

Order

CAMK2B covaries with JPH3ProteinHetionet hetionet:covaries:57338-816Inferred only
BGN interacts with JPH3ProteinHetionet hetionet:interacts:57338-633Inferred only
PPP1CA interacts with JPH3ProteinHetionet hetionet:interacts:5499-57338Inferred only
SMAD3 interacts with JPH3ProteinHetionet hetionet:interacts:4088-57338Inferred only
JPH3 regulates regulation of cardiac muscle contraction by calcium ion signalingBiological processgene ontology Q8WXH2|GO:0010882Inferred only
JPH3 regulates regulation of neuronal synaptic plasticityBiological processgene ontology Q8WXH2|GO:0048168Inferred only
JPH3 regulates regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumBiological processgene ontology Q8WXH2|GO:0010880Inferred only
JPH3 regulates regulation of synaptic plasticityBiological processgene ontology Q8WXH2|GO:0048167Inferred only

Other names

5 names

Resolves to: JPH3

Also called: JP-3JP3Junctophilin type 3TNRC22Trinucleotide repeat-containing gene 22 protein

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