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Proteins/UNIPROT:Q6GPH6
Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx..
Function from UniProtKB (Q6GPH6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 statements
4 statements · 3 reference databases · Subject: ITPRIPL1 · Sources: gene ontology, Hetionet, WikiPathways
2 names
Resolves to: ITPRIPL1