Proteins/UNIPROT:P78412

IRX6

ProteinUNIPROT:P78412

Transcription factor. Binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor. Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r. Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells..

Function from UniProtKB (P78412), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

cone dystrophy has a germline basis in IRX6DiseaseGenCC HGNC:14675|MONDO:0000455Inferred only

Statements

11 statements

11 statements · 2 reference databases · Subject: IRX6 · Sources: gene ontology, Hetionet

Order

DMRTA2 covaries with IRX6ProteinHetionet hetionet:covaries:63950-79190Inferred only
GPC3 covaries with IRX6ProteinHetionet hetionet:covaries:2719-79190Inferred only
H2AC11; H2AC13; H2AC15; H2AC16; H2AC17 covaries with IRX6ProteinHetionet hetionet:covaries:79190-8330Inferred only
H2BC15 covaries with IRX6ProteinHetionet hetionet:covaries:79190-8341Inferred only
IRX6 covaries with HOXC10ProteinHetionet hetionet:covaries:3226-79190Inferred only
IRX6 covaries with LRRC41ProteinHetionet hetionet:covaries:10489-79190Inferred only
PNKD covaries with IRX6ProteinHetionet hetionet:covaries:25953-79190Inferred only
ROS1 covaries with IRX6ProteinHetionet hetionet:covaries:6098-79190Inferred only
SNTA1 covaries with IRX6ProteinHetionet hetionet:covaries:6640-79190Inferred only
ZFP14 covaries with IRX6ProteinHetionet hetionet:covaries:57677-79190Inferred only
IRX6 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P78412|GO:0006357Inferred only

Other names

4 names

Resolves to: IRX6

Also called: Homeodomain protein IRXB3Iroquois homeobox protein 6IRX7IRXB3

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