Proteins/UNIPROT:Q12912

IRAG2

ProteinUNIPROT:Q12912

Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity)..

Function from UniProtKB (Q12912), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 2 reference databases · Subject: IRAG2 · Sources: Hetionet, Reactome

Order

IRAG2 covaries with CENPIProteinHetionet hetionet:covaries:2491-4033Inferred only
IRAG2 covaries with CFDProteinHetionet hetionet:covaries:1675-4033Inferred only
IRAG2 covaries with ZFP69BProteinHetionet hetionet:covaries:4033-65243Inferred only
IRAG2 covaries with ZNF570ProteinHetionet hetionet:covaries:148268-4033Inferred only
IRAG2 covaries with ZNF581ProteinHetionet hetionet:covaries:4033-51545Inferred only
IRAG2 interacts with YWHAEProteinHetionet hetionet:interacts:4033-7531Inferred only
IRAG2 interacts with YWHAZProteinHetionet hetionet:interacts:4033-7534Inferred only
IRAG2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IRAG2 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
IRAG2 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only

Other names

5 names

Resolves to: IRAG2

Also called: [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]JAW1LRMPLymphoid-restricted membrane proteinProtein Jaw1

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