Proteins/UNIPROT:Q9Y6F6

IRAG1

ProteinUNIPROT:Q9Y6F6

Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity)..

Function from UniProtKB (Q9Y6F6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 2 reference databases · Subject: IRAG1 · Sources: Hetionet, Reactome

Order

CASP8AP2 covaries with IRAG1ProteinHetionet hetionet:covaries:10335-9994Inferred only
IRAG1 covaries with PCDHB10ProteinHetionet hetionet:covaries:10335-56126Inferred only
IRAG1 covaries with ZFP2ProteinHetionet hetionet:covaries:10335-80108Inferred only
IRAG1 covaries with ZNF638ProteinHetionet hetionet:covaries:10335-27332Inferred only
PRKG1 interacts with IRAG1ProteinHetionet hetionet:interacts:10335-5592Inferred only
IRAG1 participates in cGMP effectsPathwayReactome R-HSA-418457Inferred only
IRAG1 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
IRAG1 participates in Nitric oxide stimulates guanylate cyclasePathwayReactome R-HSA-392154Inferred only
IRAG1 participates in Platelet homeostasisPathwayReactome R-HSA-418346Inferred only

Other names

6 names

Resolves to: IRAG1

Also called: Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrateIRAGJAW1-related protein MRVI1JAW1LMRVI1Protein MRVI1

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