Proteins/UNIPROT:Q8NA54

IQUB

ProteinUNIPROT:Q8NA54

Adapter protein that anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes. The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum. May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1. Additionally, may play a role in the functioning of cilia (By similarity). Not required for the functioning of tracheal or ependymal cilia (By similarity)..

Function from UniProtKB (Q8NA54), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

4 statements

4 statements · 2 reference databases · Subject: IQUB · Sources: Hetionet, WikiPathways

Order

IQUB covaries with CCDC15ProteinHetionet hetionet:covaries:154865-80071Inferred only
MDFI interacts with IQUBProteinHetionet hetionet:interacts:154865-4188Inferred only
IQUB participates in 10q22q23 copy number variationPathwayWikiPathways WP5402Inferred only
IQUB participates in 22q11 2 distal CNVPathwayWikiPathways WP5546Inferred only

Other names

1 name

Resolves to: IQUB

Also called: IQ motif and ubiquitin-like domain-containing protein

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