Proteins/UNIPROT:Q86SU0

ILDR1

ProteinUNIPROT:Q86SU0

Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity)..

(Microbial infection) Promotes influenza virus infection by inhibiting viral nucleoprotein NP binding to PLSCR1 and thereby PLSCR1-mediated antiviral activity..

Function from UniProtKB (Q86SU0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

autosomal recessive nonsyndromic hearing loss 42 has a germline basis in ILDR1DiseaseGenCC HGNC:28741|MONDO:0012326Inferred only
hearing loss, autosomal recessive has a germline basis in ILDR1DiseaseGenCC HGNC:28741|MONDO:0019588Inferred only
nonsyndromic genetic hearing loss has a germline basis in ILDR1DiseaseGenCC HGNC:28741|MONDO:0019497Inferred only

Statements

6 statements

6 statements · 2 reference databases · Subject: ILDR1 · Sources: gene ontology, Hetionet

Order

ASPDH covaries with ILDR1ProteinHetionet hetionet:covaries:286676-554235Inferred only
ILDR1 covaries with FAM181BProteinHetionet hetionet:covaries:220382-286676Inferred only
ILDR1 covaries with FRAT2ProteinHetionet hetionet:covaries:23401-286676Inferred only
OBSCN covaries with ILDR1ProteinHetionet hetionet:covaries:286676-84033Inferred only
ILDR1 regulates positive regulation of peptide hormone secretionBiological processgene ontology Q86SU0|GO:0090277Inferred only
ILDR1 regulates regulation of RNA splicingBiological processgene ontology Q86SU0|GO:0043484Inferred only

Other names

2 names

Resolves to: ILDR1

Also called: Angulin-2Immunoglobulin-like domain-containing receptor 1

← Every protein Find it in the graph →