Proteins/UNIPROT:Q969J5

IL22RA2

ProteinUNIPROT:Q969J5

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.

Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Function from UniProtKB (Q969J5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: IL22RA2 · Sources: gene ontology, Hetionet, Reactome

Order

IL22RA2 covaries with BRME1ProteinHetionet hetionet:covaries:116379-79173Inferred only
IL22RA2 covaries with ZNF180ProteinHetionet hetionet:covaries:116379-7733Inferred only
IL22 interacts with IL22RA2ProteinHetionet hetionet:interacts:116379-50616Inferred only
IL22RA2 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
IL22RA2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IL22RA2 participates in Interleukin-20 family signalingPathwayReactome R-HSA-8854691Inferred only
IL22RA2 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
IL22RA2 regulates negative regulation of inflammatory responseBiological processgene ontology Q969J5|GO:0050728Inferred only

Other names

12 names

Resolves to: IL22RA2

Also called: CRF2-10CRF2-S1Cytokine receptor class-II member 10Cytokine receptor family 2 member 10Cytokine receptor family type 2, soluble 1IL-22 receptor subunit alpha-2IL-22BPIL-22R-alpha-2IL-22RA2IL22BPInterleukin-22-binding proteinZcytoR16

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