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Proteins/UNIPROT:Q8IYA8
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance..
Function from UniProtKB (Q8IYA8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 statements
4 statements · 3 reference databases · Subject: IHO1 · Sources: gene ontology, Hetionet, WikiPathways
4 names
Resolves to: IHO1