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Proteins/UNIPROT:P47898
G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR5A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores..
Function from UniProtKB (P47898), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 statements
9 statements · 2 reference databases · Subject: HTR5A · Sources: Hetionet, Reactome
4 names
Resolves to: HTR5A