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Proteins/UNIPROT:Q13639

HTR4

Protein·UNIPROT:Q13639

Open in the graph

G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity..

Function from UniProtKB (Q13639), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

15 statements

15 statements · 4 reference databases · Subject: HTR4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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HTR4 covaries with PHB2ProteinHetionet hetionet:covaries:11331-3360Inferred only
HTR4 interacts with UBCProteinHetionet hetionet:interacts:3360-7316Inferred only
HTR4 participates in Amine ligand-binding receptorsPathwayReactome R-HSA-375280Inferred only
HTR4 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
HTR4 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
HTR4 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
HTR4 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
HTR4 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
HTR4 participates in Monoamine GPCRsPathwayWikiPathways WP58Inferred only
HTR4 participates in Serotonin receptor 4 6 7 and NR3C signalingPathwayWikiPathways WP734Inferred only
HTR4 participates in Serotonin receptorsPathwayReactome R-HSA-390666Inferred only
HTR4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 3

HTR4 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
HTR4 regulates regulation of appetiteBiological processgene ontology Q13639|GO:0032098Inferred only
HTR4 regulates regulation of postsynapse assemblyBiological processgene ontology Q13639|GO:0150052Inferred only

Other names

3 names

Resolves to: HTR4

Also called: 5-HT-45-HT4Serotonin receptor 4

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