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Proteins/UNIPROT:P30939

HTR1F

Protein·UNIPROT:P30939

Open in the graph

G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Receptor for lasmiditan, a drug for the treatment of acute migraine. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity..

Function from UniProtKB (P30939), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

13 statements

13 statements · 3 reference databases · Subject: HTR1F · Sources: Hetionet, Reactome, WikiPathways

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CAV1 interacts with HTR1FProteinHetionet hetionet:interacts:3355-857Inferred only
HTR1F participates in Amine ligand-binding receptorsPathwayReactome R-HSA-375280Inferred only
HTR1F participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
HTR1F participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
HTR1F participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
HTR1F participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
HTR1F participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
HTR1F participates in GPCRs otherPathwayWikiPathways WP117Inferred only
HTR1F participates in Monoamine GPCRsPathwayWikiPathways WP58Inferred only
HTR1F participates in Serotonin HTR1 group and FOS pathwayPathwayWikiPathways WP722Inferred only
HTR1F participates in Serotonin receptorsPathwayReactome R-HSA-390666Inferred only
HTR1F participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 1

HTR1F participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Other names

4 names

Resolves to: HTR1F

Also called: 5-HT-1F5-HT1FHTR1ELSerotonin receptor 1F

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