Proteins/UNIPROT:P28566

HTR1E

ProteinUNIPROT:P28566

G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1E is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity..

Function from UniProtKB (P28566), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

25 statements

25 statements · 3 reference databases · Subject: HTR1E · Sources: Hetionet, Reactome, WikiPathways

Order

HTR1E covaries with ACKR3ProteinHetionet hetionet:covaries:3354-57007Inferred only
HTR1E covaries with ARMC6ProteinHetionet hetionet:covaries:3354-93436Inferred only
HTR1E covaries with ASIC4ProteinHetionet hetionet:covaries:3354-55515Inferred only
HTR1E covaries with FNDC11ProteinHetionet hetionet:covaries:3354-79025Inferred only
HTR1E covaries with HOXB5ProteinHetionet hetionet:covaries:3215-3354Inferred only
HTR1E covaries with KCTD10ProteinHetionet hetionet:covaries:3354-83892Inferred only
KLHL32 covaries with HTR1EProteinHetionet hetionet:covaries:114792-3354Inferred only
HTR1E covaries with LRRC8EProteinHetionet hetionet:covaries:3354-80131Inferred only
POLR2J covaries with HTR1EProteinHetionet hetionet:covaries:3354-5439Inferred only
PPP6C covaries with HTR1EProteinHetionet hetionet:covaries:3354-5537Inferred only
RPS27A covaries with HTR1EProteinHetionet hetionet:covaries:3354-6233Inferred only
SMTN covaries with HTR1EProteinHetionet hetionet:covaries:3354-6525Inferred only

Show the remaining 13

HTR1E covaries with TLE3ProteinHetionet hetionet:covaries:3354-7090Inferred only
HTR1E covaries with UNIPROT:A0A0A6YYL4ProteinHetionet hetionet:covaries:100529144-3354Inferred only
HTR1E participates in Amine ligand-binding receptorsPathwayReactome R-HSA-375280Inferred only
HTR1E participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
HTR1E participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
HTR1E participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
HTR1E participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
HTR1E participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
HTR1E participates in Monoamine GPCRsPathwayWikiPathways WP58Inferred only
HTR1E participates in Serotonin HTR1 group and FOS pathwayPathwayWikiPathways WP722Inferred only
HTR1E participates in Serotonin receptorsPathwayReactome R-HSA-390666Inferred only
HTR1E participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
HTR1E participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Other names

4 names

Resolves to: HTR1E

Also called: 5-HT-1E5-HT1ES31Serotonin receptor 1E

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