Proteins/UNIPROT:P25021

HRH2

ProteinUNIPROT:P25021

G protein-coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels. This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release (By similarity)..

Function from UniProtKB (P25021), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 4 reference databases · Subject: HRH2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

HRH2 interacts with GPRASP1ProteinHetionet hetionet:interacts:3274-9737Inferred only
HRH2 interacts with GPRASP2ProteinHetionet hetionet:interacts:114928-3274Inferred only
HRH2 participates in Amine ligand-binding receptorsPathwayReactome R-HSA-375280Inferred only
HRH2 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
HRH2 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
HRH2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
HRH2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
HRH2 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
HRH2 participates in Histamine receptorsPathwayReactome R-HSA-390650Inferred only
HRH2 participates in Monoamine GPCRsPathwayWikiPathways WP58Inferred only
HRH2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
HRH2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Show the remaining 1

HRH2 regulates positive regulation of vasoconstrictionBiological processgene ontology P25021|GO:0045907Inferred only

Other names

3 names

Resolves to: HRH2

Also called: Gastric receptor IH2RHH2R

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