Proteins/UNIPROT:Q92902

HPS1

ProteinUNIPROT:Q92902

Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38..

Function from UniProtKB (Q92902), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

Hermansky-Pudlak syndrome 1 has a germline basis in HPS1DiseaseGenCC HGNC:5163|MONDO:0008748Inferred only
Hermansky-Pudlak syndrome with pulmonary fibrosis has a germline basis in HPS1DiseaseGenCC HGNC:5163|MONDO:0016501Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: HPS1 · Sources: Hetionet, Reactome

Order

HPS1 interacts with HPS4ProteinHetionet hetionet:interacts:3257-89781Inferred only
HPS1 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
HPS1 participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
HPS1 participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
HPS1 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

3 names

Resolves to: HPS1

Also called: BLOC-3 complex member HPS1Hermansky-Pudlak syndrome 1 proteinHPS

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