Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P13765

HLA-DOB

Protein·UNIPROT:P13765

Open in the graph

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Function from UniProtKB (P13765), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: HLA-DOB · Sources: gene ontology, Reactome, WikiPathways

Search this listOrder

HLA-DOB participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
HLA-DOB participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
HLA-DOB participates in Allograft rejectionPathwayWikiPathways WP2328Inferred only
HLA-DOB participates in Ebola virus infection in hostPathwayWikiPathways WP4217Inferred only
HLA-DOB participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
HLA-DOB participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
HLA-DOB participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
HLA-DOB participates in Processing of antigen in germinal center B cellsPathwayReactome R-HSA-9979719Inferred only
HLA-DOB regulates negative regulation of antigen processing and presentation of peptide antigen via MHC class IIBiological processgene ontology P13765|GO:0002587Inferred only
HLA-DOB regulates positive regulation of immune responseBiological processgene ontology P13765|GO:0050778Inferred only
HLA-DOB regulates positive regulation of T cell activationBiological processgene ontology P13765|GO:0050870Inferred only

Other names

2 names

Resolves to: HLA-DOB

Also called: HLA class II histocompatibility antigen, DO beta chainMHC class II antigen DOB

← Every protein Find it in the graph →