Proteins/UNIPROT:P07305

H1-0

ProteinUNIPROT:P07305

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division..

Function from UniProtKB (P07305), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

34 statements

34 statements · 3 reference databases · Subject: H1-0 · Sources: gene ontology, Hetionet, Reactome

Order

CCDC9 covaries with H1-0ProteinHetionet hetionet:covaries:26093-3005Inferred only
PCDHB15 covaries with H1-0ProteinHetionet hetionet:covaries:3005-56121Inferred only
H1-0 covaries with TRIM6-TRIM34ProteinHetionet hetionet:covaries:3005-445372Inferred only
APP interacts with H1-0ProteinHetionet hetionet:interacts:3005-351Inferred only
H1-0 interacts with CAND1ProteinHetionet hetionet:interacts:3005-55832Inferred only
CCNE1 interacts with H1-0ProteinHetionet hetionet:interacts:3005-898Inferred only
CDK1 interacts with H1-0ProteinHetionet hetionet:interacts:3005-983Inferred only
CDK2 interacts with H1-0ProteinHetionet hetionet:interacts:1017-3005Inferred only
CDK4 interacts with H1-0ProteinHetionet hetionet:interacts:1019-3005Inferred only
CDK5 interacts with H1-0ProteinHetionet hetionet:interacts:1020-3005Inferred only
GRB2 interacts with H1-0ProteinHetionet hetionet:interacts:2885-3005Inferred only
H1-0 interacts with HDGFProteinHetionet hetionet:interacts:3005-3068Inferred only

Show the remaining 22

H1-0 interacts with IKBKGProteinHetionet hetionet:interacts:3005-8517Inferred only
H1-0 interacts with IPO5ProteinHetionet hetionet:interacts:3005-3843Inferred only
H1-0 interacts with IPO7ProteinHetionet hetionet:interacts:10527-3005Inferred only
H1-0 interacts with NEDD4LProteinHetionet hetionet:interacts:23327-3005Inferred only
H1-0 interacts with NOA1ProteinHetionet hetionet:interacts:3005-84273Inferred only
H1-0 interacts with PRKCBProteinHetionet hetionet:interacts:3005-5579Inferred only
H1-0 interacts with RAD51BProteinHetionet hetionet:interacts:3005-5890Inferred only
H1-0 interacts with UBCProteinHetionet hetionet:interacts:3005-7316Inferred only
H1-0 interacts with XBP1ProteinHetionet hetionet:interacts:3005-7494Inferred only
H1-0 participates in ApoptosisPathwayReactome R-HSA-109581Inferred only
H1-0 participates in Apoptosis induced DNA fragmentationPathwayReactome R-HSA-140342Inferred only
H1-0 participates in Apoptotic execution phasePathwayReactome R-HSA-75153Inferred only
H1-0 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
H1-0 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
H1-0 participates in Cellular SenescencePathwayReactome R-HSA-2559583Inferred only
H1-0 participates in DNA Damage/Telomere Stress Induced SenescencePathwayReactome R-HSA-2559586Inferred only
H1-0 participates in Formation of Senescence-Associated Heterochromatin Foci (SAHF)PathwayReactome R-HSA-2559584Inferred only
H1-0 participates in Programmed Cell DeathPathwayReactome R-HSA-5357801Inferred only
H1-0 regulates negative regulation of DNA recombinationBiological processgene ontology P07305|GO:0045910Inferred only
H1-0 regulates positive regulation of transcription regulatory region DNA bindingBiological processgene ontology P07305|GO:2000679Inferred only
GPSM1 increases the expression of H1-0ProteinHetionet hetionet:regulates:26086-3005Inferred only
LCK decreases the expression of H1-0ProteinHetionet hetionet:regulates:3932-3005Inferred only

Other names

5 names

Resolves to: H1-0

Also called: [Cleaved into: Histone H1.0, N-terminally processed]H1F0H1FVHistone H1'Histone H1(0)

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