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Proteins/UNIPROT:P20718

GZMH

Protein·UNIPROT:P20718

Open in the graph

Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication..

Function from UniProtKB (P20718), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

5 statements

5 statements · 2 reference databases · Subject: GZMH · Sources: Hetionet, Reactome

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GZMH interacts with SSBProteinHetionet hetionet:interacts:2999-6741Inferred only
GZMH participates in Metabolism of Angiotensinogen to AngiotensinsPathwayReactome R-HSA-2022377Inferred only
GZMH participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
GZMH participates in Peptide hormone metabolismPathwayReactome R-HSA-2980736Inferred only
GZMH participates in Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PathwayReactome R-HSA-381426Inferred only

Other names

7 names

Resolves to: GZMH

Also called: Cathepsin G-like 2CCP-XCGL2CSP-CCTSGL2Cytotoxic serine protease CCytotoxic T-lymphocyte proteinase

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