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Proteins/UNIPROT:O00222

GRM8

Protein·UNIPROT:O00222

Open in the graph

G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity..

Function from UniProtKB (O00222), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

14 statements

14 statements · 4 reference databases · Subject: GRM8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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FLNA interacts with GRM8ProteinHetionet hetionet:interacts:2316-2918Inferred only
GRM8 interacts with GPRASP1ProteinHetionet hetionet:interacts:2918-9737Inferred only
GRM8 interacts with PIAS1ProteinHetionet hetionet:interacts:2918-8554Inferred only
GRM8 interacts with PIAS2ProteinHetionet hetionet:interacts:2918-9063Inferred only
GRM8 participates in Class C/3 (Metabotropic glutamate/pheromone receptors)PathwayReactome R-HSA-420499Inferred only
GRM8 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
GRM8 participates in GABA and glutamate signalling in epileptogenesisPathwayWikiPathways WP5600Inferred only
GRM8 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GRM8 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
GRM8 participates in GPCRs class C metabotropic glutamate pheromonePathwayWikiPathways WP501Inferred only
GRM8 participates in Neuroinflammation and glutamatergic signalingPathwayWikiPathways WP5083Inferred only
GRM8 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 2

GRM8 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
GRM8 regulates regulation of synaptic transmission, glutamatergicBiological processgene ontology O00222|GO:0051966Inferred only

Other names

3 names

Resolves to: GRM8

Also called: GPRC1HMetabotropic glutamate receptor 8MGLUR8

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