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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q14831

GRM7

Protein·UNIPROT:Q14831

Open in the graph

G protein-coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits..

Function from UniProtKB (Q14831), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities has a germline basis in GRM7DiseaseGenCC HGNC:4599|MONDO:0030063Inferred only

Statements

25 statements

25 statements · 4 reference databases · Subject: GRM7 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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GPRIN1 covaries with GRM7ProteinHetionet hetionet:covaries:114787-2917Inferred only
GRM7 covaries with SBK1ProteinHetionet hetionet:covaries:2917-388228Inferred only
CALM1 interacts with GRM7ProteinHetionet hetionet:interacts:2917-805Inferred only
CALM1 interacts with GRM7ProteinHetionet hetionet:interacts:2917-801Inferred only
CALM1 interacts with GRM7ProteinHetionet hetionet:interacts:2917-808Inferred only
FLNA interacts with GRM7ProteinHetionet hetionet:interacts:2316-2917Inferred only
GNAQ interacts with GRM7ProteinHetionet hetionet:interacts:2776-2917Inferred only
GRM7 interacts with GRIPAP1ProteinHetionet hetionet:interacts:2917-56850Inferred only
GRM7 interacts with PICK1ProteinHetionet hetionet:interacts:2917-9463Inferred only
GRM7 interacts with TUBA1AProteinHetionet hetionet:interacts:2917-7846Inferred only
GRM7 interacts with TUBA1BProteinHetionet hetionet:interacts:10376-2917Inferred only
GRM7 interacts with TUBA4AProteinHetionet hetionet:interacts:2917-7277Inferred only

Show the remaining 13

GRM7 interacts with TUBA8ProteinHetionet hetionet:interacts:2917-51807Inferred only
GRM7 interacts with UBCProteinHetionet hetionet:interacts:2917-7316Inferred only
GRM7 participates in Class C/3 (Metabotropic glutamate/pheromone receptors)PathwayReactome R-HSA-420499Inferred only
GRM7 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
GRM7 participates in GABA and glutamate signalling in epileptogenesisPathwayWikiPathways WP5600Inferred only
GRM7 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GRM7 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
GRM7 participates in GPCRs class C metabotropic glutamate pheromonePathwayWikiPathways WP501Inferred only
GRM7 participates in Neuroinflammation and glutamatergic signalingPathwayWikiPathways WP5083Inferred only
GRM7 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GRM7 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
GRM7 regulates negative regulation of glutamate secretionBiological processgene ontology Q14831|GO:0014050Inferred only
GRM7 regulates regulation of synaptic transmission, glutamatergicBiological processgene ontology Q14831|GO:0051966Inferred only

Other names

3 names

Resolves to: GRM7

Also called: GPRC1GMetabotropic glutamate receptor 7MGLUR7

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