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Proteins/UNIPROT:O95800
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor..
Function from UniProtKB (O95800), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 2 reference databases · Subject: GPR75 · Sources: Hetionet, WikiPathways
1 name
Resolves to: GPR75