Proteins/UNIPROT:Q9Y5Y3

GPR45

ProteinUNIPROT:Q9Y5Y3

Protein carrier that acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus (PVH) by mediating transport of G(s) into primary cilia (By similarity). Transported into primary cilia of PVH neurons via its association with TULP3 and carries G(s) into the primary cilia to support MC4R activity and activate ADCY3, leading to cAMP production, which signals to suppress appetite (By similarity). Does not act as a canonical G protein-coupled receptor: does not promote the exchange of GDP for GTP on G(s) protein but mediates G(s) translocation into primary cilia (By similarity)..

Function from UniProtKB (Q9Y5Y3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 4 reference databases · Subject: GPR45 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ABL1 interacts with GPR45ProteinHetionet hetionet:interacts:11250-25Inferred only
FYN interacts with GPR45ProteinHetionet hetionet:interacts:11250-2534Inferred only
GRB2 interacts with GPR45ProteinHetionet hetionet:interacts:11250-2885Inferred only
NCK1 interacts with GPR45ProteinHetionet hetionet:interacts:11250-4690Inferred only
GPR45 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
GPR45 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GPR45 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
GPR45 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GPR45 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
GPR45 regulates negative regulation of appetiteBiological processgene ontology Q9Y5Y3|GO:0032099Inferred only

Other names

1 name

Resolves to: GPR45

Also called: Probable G protein-coupled receptor 45

← Every protein Find it in the graph →