Proteins/UNIPROT:O00155

GPR25

ProteinUNIPROT:O00155

Receptor for the C-X-C chemokine CXCL17, which plays a key role in lymphocyte homing. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. Activation by CXCL17 on lymphocytes activates the RhoA pathway, which regulates cytoskeletal dynamics and integrins, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts..

Function from UniProtKB (O00155), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 3 reference databases · Subject: GPR25 · Sources: Hetionet, Reactome, WikiPathways

Order

GPR25 interacts with MAP3K7ProteinHetionet hetionet:interacts:2848-6885Inferred only
GPR25 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
GPR25 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GPR25 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
GPR25 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GPR25 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Other names

2 names

Resolves to: GPR25

Also called: C-X-C chemokine receptor GPR25G protein-coupled receptor 25

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