Proteins/UNIPROT:Q6UWK7

GPR15LG

ProteinUNIPROT:Q6UWK7

Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G protein-coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation..

Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus..

Function from UniProtKB (Q6UWK7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 3 reference databases · Subject: GPR15LG · Sources: gene ontology, Hetionet, WikiPathways

Order

ASIC5 covaries with GPR15LGProteinHetionet hetionet:covaries:387695-51802Inferred only
GLDN covaries with GPR15LGProteinHetionet hetionet:covaries:342035-387695Inferred only
GPR15LG participates in 10q22q23 copy number variationPathwayWikiPathways WP5402Inferred only
GPR15LG regulates negative regulation of cell cycle G1/S phase transitionBiological processgene ontology Q6UWK7|GO:1902807Inferred only
GPR15LG regulates negative regulation of cell divisionBiological processgene ontology Q6UWK7|GO:0051782Inferred only
GPR15LG regulates regulation of keratinocyte proliferationBiological processgene ontology Q6UWK7|GO:0010837Inferred only
GPR15LG regulates regulation of T cell migrationBiological processgene ontology Q6UWK7|GO:2000404Inferred only

Other names

11 names

Resolves to: GPR15LG

Also called: Antimicrobial peptide with 57 amino acid residuesAntimicrobial peptide-57AP-57C10orf99Colon-derived SUSD2 binding factorCSBFGPR15 ligandGPR15LProtein GPR15 ligandProtein GPR15LSecreted protein C10orf99

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