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Proteins/UNIPROT:Q7Z3F1
Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway. Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling. Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition. Binds indole-3-acetic acid and may play a role in tryptophan metabolism..
Function from UniProtKB (Q7Z3F1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 2 reference databases · Subject: GPR155 · Sources: gene ontology, Hetionet
3 names
Resolves to: GPR155