GPR12

Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (By similarity). Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production. Also engages the G(i)/G(o) pathway, which counteracts the cAMP increase driven by G(s) activation. Additionally, two lipids sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) may act as endogenous ligand and activate GPR12..

Function from UniProtKB (P47775), read 2026-09-23. CC BY 4.0.