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Proteins/UNIPROT:Q86YW7

GPHB5

Protein·UNIPROT:Q86YW7

Open in the graph

Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism..

Function from UniProtKB (Q86YW7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

9 statements

9 statements · 2 reference databases · Subject: GPHB5 · Sources: Hetionet, Reactome

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GPHB5 covaries with ZBED2ProteinHetionet hetionet:covaries:122876-79413Inferred only
GPHB5 interacts with GPHA2ProteinHetionet hetionet:interacts:122876-170589Inferred only
GPHB5 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
GPHB5 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
GPHB5 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GPHB5 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
GPHB5 participates in Hormone ligand-binding receptorsPathwayReactome R-HSA-375281Inferred only
GPHB5 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GPHB5 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Other names

4 names

Resolves to: GPHB5

Also called: Glycoprotein hormone beta-5GPB5Thyrostimulin subunit betaZLUT1

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