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Proteins/UNIPROT:Q9UK05

GDF2

Protein·UNIPROT:Q9UK05

Open in the graph

Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG..

Function from UniProtKB (Q9UK05), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

4 rows

hereditary hemorrhagic telangiectasia has a germline basis in GDF2DiseaseGenCC HGNC:4217|MONDO:0019180Inferred only
pulmonary arterial hypertension has a germline basis in GDF2DiseaseGenCC HGNC:4217|MONDO:0015924Inferred only
telangiectasia, hereditary hemorrhagic, type 1 has a germline basis in GDF2DiseaseGenCC HGNC:4217|MONDO:0008535Inferred only
telangiectasia, hereditary hemorrhagic, type 5 has a germline basis in GDF2DiseaseGenCC HGNC:4217|MONDO:0014217Inferred only

Statements

25 statements

25 statements · 4 reference databases · Subject: GDF2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CXCL2 covaries with GDF2ProteinHetionet hetionet:covaries:2658-2920Inferred only
GDF10 covaries with GDF2ProteinHetionet hetionet:covaries:2658-2662Inferred only
GDF2 covaries with ZNF488ProteinHetionet hetionet:covaries:118738-2658Inferred only
GDF2 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
GDF2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GDF2 participates in Signaling by BMPPathwayReactome R-HSA-201451Inferred only
GDF2 participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
GDF2 regulates negative regulation of angiogenesisBiological processgene ontology Q9UK05|GO:0016525Inferred only
GDF2 regulates negative regulation of blood vessel endothelial cell migrationBiological processgene ontology Q9UK05|GO:0043537Inferred only
GDF2 regulates negative regulation of cell growthBiological processgene ontology Q9UK05|GO:0030308Inferred only
GDF2 regulates negative regulation of DNA replicationBiological processgene ontology Q9UK05|GO:0008156Inferred only
GDF2 regulates negative regulation of endothelial cell migrationBiological processgene ontology Q9UK05|GO:0010596Inferred only

Show the remaining 13

GDF2 regulates negative regulation of endothelial cell proliferationBiological processgene ontology Q9UK05|GO:0001937Inferred only
GDF2 regulates positive regulation of angiogenesisBiological processgene ontology Q9UK05|GO:0045766Inferred only
GDF2 regulates positive regulation of bicellular tight junction assemblyBiological processgene ontology Q9UK05|GO:1903348Inferred only
GDF2 regulates positive regulation of BMP signaling pathwayBiological processgene ontology Q9UK05|GO:0030513Inferred only
GDF2 regulates positive regulation of cartilage developmentBiological processgene ontology Q9UK05|GO:0061036Inferred only
GDF2 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q9UK05|GO:0045893Inferred only
GDF2 regulates positive regulation of endothelial cell differentiationBiological processgene ontology Q9UK05|GO:0045603Inferred only
GDF2 regulates positive regulation of endothelial cell proliferationBiological processgene ontology Q9UK05|GO:0001938Inferred only
GDF2 regulates positive regulation of epithelial cell differentiationBiological processgene ontology Q9UK05|GO:0030858Inferred only
GDF2 regulates positive regulation of interleukin-8 productionBiological processgene ontology Q9UK05|GO:0032757Inferred only
GDF2 regulates positive regulation of Notch signaling pathwayBiological processgene ontology Q9UK05|GO:0045747Inferred only
GDF2 regulates positive regulation of SMAD protein signal transductionBiological processgene ontology Q9UK05|GO:0060391Inferred only
GDF2 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UK05|GO:0045944Inferred only

Other names

4 names

Resolves to: GDF2

Also called: BMP-9BMP9Bone morphogenetic protein 9GDF-2

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