Proteins/UNIPROT:Q9P2Q2

FRMD4A

ProteinUNIPROT:Q9P2Q2

Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling..

Function from UniProtKB (Q9P2Q2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome has a germline basis in FRMD4ADiseaseGenCC HGNC:25491|MONDO:0014787Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: FRMD4A · Sources: gene ontology, Hetionet

Order

KRTAP13-1 covaries with FRMD4AProteinHetionet hetionet:covaries:140258-55691Inferred only
KRTAP5-6 covaries with FRMD4AProteinHetionet hetionet:covaries:440023-55691Inferred only
FRMD4A covaries with MAP1LC3CProteinHetionet hetionet:covaries:440738-55691Inferred only
NTF4 covaries with FRMD4AProteinHetionet hetionet:covaries:4909-55691Inferred only
IFT54 interacts with FRMD4AProteinHetionet hetionet:interacts:26146-55691Inferred only
YEATS4 interacts with FRMD4AProteinHetionet hetionet:interacts:55691-8089Inferred only
FRMD4A regulates negative regulation of protein secretionBiological processgene ontology Q9P2Q2|GO:0050709Inferred only
FRMD4A regulates positive regulation of protein secretionBiological processgene ontology Q9P2Q2|GO:0050714Inferred only

Other names

3 names

Resolves to: FRMD4A

Also called: FERM domain-containing protein 4AFRMD4KIAA1294

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