Proteins/UNIPROT:P42685

FRK

ProteinUNIPROT:P42685

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor..

Function from UniProtKB (P42685), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

23 statements

23 statements · 3 reference databases · Subject: FRK · Sources: gene ontology, Hetionet, Reactome

Order

FRK covaries with AIM2ProteinHetionet hetionet:covaries:2444-9447Inferred only
FRK covaries with NPBProteinHetionet hetionet:covaries:2444-256933Inferred only
OR10J1 covaries with FRKProteinHetionet hetionet:covaries:2444-26476Inferred only
FRK covaries with TMEM200CProteinHetionet hetionet:covaries:2444-645369Inferred only
FRK interacts with ABI1ProteinHetionet hetionet:interacts:10006-2444Inferred only
FRK interacts with HSP90AA1ProteinHetionet hetionet:interacts:2444-3320Inferred only
FRK interacts with HSP90AB1ProteinHetionet hetionet:interacts:2444-3326Inferred only
FRK interacts with KHDRBS1ProteinHetionet hetionet:interacts:10657-2444Inferred only
FRK interacts with PTENProteinHetionet hetionet:interacts:2444-5728Inferred only
FRK interacts with RAC1ProteinHetionet hetionet:interacts:2444-5879Inferred only
FRK interacts with RB1ProteinHetionet hetionet:interacts:2444-5925Inferred only
FRK interacts with SF3B4ProteinHetionet hetionet:interacts:10262-2444Inferred only

Show the remaining 11

FRK participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
FRK participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
FRK participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
FRK participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
FRK participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
FRK participates in PTEN RegulationPathwayReactome R-HSA-6807070Inferred only
FRK participates in Regulation of PTEN stability and activityPathwayReactome R-HSA-8948751Inferred only
FRK participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FRK regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology P42685|GO:0000122Inferred only
FRK decreases the expression of ARID4BProteinHetionet hetionet:regulates:2444-51742Inferred only
FRK increases the expression of IGF2BP2ProteinHetionet hetionet:regulates:2444-10644Inferred only

Reactions

1 reaction

L-tyrosyl-[protein]+ATP(4-)O-phospho-L-tyrosyl-[protein]+ADP(3-)+hydron
Catalysed by MAP2K7 or MUSK or RIPK2 or DYRK3 or JAK2 or STK16 or ABL1 or EGFR or ERBB2 or NTRK1 or INSR or LCK and 104 more alternatives
Reaction page

Other names

5 names

Resolves to: FRK

Also called: FYN-related kinaseNuclear tyrosine protein kinase RAKProtein-tyrosine kinase 5PTK5RAK

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