Proteins/UNIPROT:Q6ZNL6

FGD5

ProteinUNIPROT:Q6ZNL6

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape..

Function from UniProtKB (Q6ZNL6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 4 reference databases · Subject: FGD5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

FGD5 covaries with ARRDC2ProteinHetionet hetionet:covaries:152273-27106Inferred only
DCAF12L1 covaries with FGD5ProteinHetionet hetionet:covaries:139170-152273Inferred only
FGD5 covaries with HSH2DProteinHetionet hetionet:covaries:152273-84941Inferred only
FGD5 covaries with KPNA2ProteinHetionet hetionet:covaries:152273-3838Inferred only
MYO9B covaries with FGD5ProteinHetionet hetionet:covaries:152273-4650Inferred only
TREML2 covaries with FGD5ProteinHetionet hetionet:covaries:152273-79865Inferred only
FGD5 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
FGD5 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
FGD5 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FGD5 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
FGD5 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
FGD5 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only

Show the remaining 3

FGD5 regulates regulation of cell shapeBiological processgene ontology Q6ZNL6|GO:0008360Inferred only
FGD5 regulates regulation of GTPase activityBiological processgene ontology Q6ZNL6|GO:0043087Inferred only
FGD5 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q6ZNL6|GO:0051056Inferred only

Other names

3 names

Resolves to: FGD5

Also called: FYVE, RhoGEF and PH domain-containing protein 5ZFYVE23Zinc finger FYVE domain-containing protein 23

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