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Proteins/UNIPROT:Q7Z6J4

FGD2

Protein·UNIPROT:Q7Z6J4

Open in the graph

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity)..

Function from UniProtKB (Q7Z6J4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

16 statements

16 statements · 3 reference databases · Subject: FGD2 · Sources: gene ontology, Hetionet, Reactome

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UBC interacts with FGD2ProteinHetionet hetionet:interacts:221472-7316Inferred only
FGD2 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
FGD2 participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
FGD2 participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
FGD2 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
FGD2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
FGD2 participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
FGD2 participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
FGD2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
FGD2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FGD2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
FGD2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only

Show the remaining 4

FGD2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
FGD2 regulates regulation of cell shapeBiological processgene ontology Q7Z6J4|GO:0008360Inferred only
FGD2 regulates regulation of GTPase activityBiological processgene ontology Q7Z6J4|GO:0043087Inferred only
FGD2 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q7Z6J4|GO:0051056Inferred only

Other names

3 names

Resolves to: FGD2

Also called: FYVE, RhoGEF and PH domain-containing protein 2ZFYVE4Zinc finger FYVE domain-containing protein 4

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