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Proteins/UNIPROT:P12314

FCGR1A

Protein·UNIPROT:P12314

Open in the graph

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells..

Function from UniProtKB (P12314), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

41 statements

41 statements · 4 reference databases · Subject: FCGR1A · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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APCS interacts with FCGR1AProteinHetionet hetionet:interacts:2209-325Inferred only
CBL interacts with FCGR1AProteinHetionet hetionet:interacts:2209-867Inferred only
CRKL interacts with FCGR1AProteinHetionet hetionet:interacts:1399-2209Inferred only
CRP interacts with FCGR1AProteinHetionet hetionet:interacts:1401-2209Inferred only
FCAR interacts with FCGR1AProteinHetionet hetionet:interacts:2204-2209Inferred only
FCGR1A interacts with FCGR3AProteinHetionet hetionet:interacts:2209-2214Inferred only
FCGR1A interacts with HCKProteinHetionet hetionet:interacts:2209-3055Inferred only
FCGR1A interacts with HRGProteinHetionet hetionet:interacts:2209-3273Inferred only
FCGR1A interacts with LATProteinHetionet hetionet:interacts:2209-27040Inferred only
FCGR1A interacts with LCP2ProteinHetionet hetionet:interacts:2209-3937Inferred only
FCGR1A interacts with LILRB2ProteinHetionet hetionet:interacts:10288-2209Inferred only
FCGR1A interacts with SHC1ProteinHetionet hetionet:interacts:2209-6464Inferred only

Show the remaining 29

FCGR1A interacts with SYKProteinHetionet hetionet:interacts:2209-6850Inferred only
FCGR1A participates in Acute myeloid leukemiaPathwayWikiPathways WP5293Inferred only
FCGR1A participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
FCGR1A participates in Anti-inflammatory response favouring Leishmania parasite infectionPathwayReactome R-HSA-9662851Inferred only
FCGR1A participates in Antigen processing-Cross presentationPathwayReactome R-HSA-1236975Inferred only
FCGR1A participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
FCGR1A participates in Cross-presentation of soluble exogenous antigens (endosomes)PathwayReactome R-HSA-1236978Inferred only
FCGR1A participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
FCGR1A participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
FCGR1A participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
FCGR1A participates in Differentiation of Circulating MonocytesPathwayReactome R-HSA-9968734Inferred only
FCGR1A participates in DiseasePathwayReactome R-HSA-1643685Inferred only
FCGR1A participates in Fcgamma receptor (FCGR) dependent phagocytosisPathwayReactome R-HSA-2029480Inferred only
FCGR1A participates in FCGR activationPathwayReactome R-HSA-2029481Inferred only
FCGR1A participates in FCGR3A-mediated IL10 synthesisPathwayReactome R-HSA-9664323Inferred only
FCGR1A participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
FCGR1A participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellPathwayReactome R-HSA-198933Inferred only
FCGR1A participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
FCGR1A participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
FCGR1A participates in Interferon gamma signalingPathwayReactome R-HSA-877300Inferred only
FCGR1A participates in Interferon SignalingPathwayReactome R-HSA-913531Inferred only
FCGR1A participates in Leishmania infectionPathwayReactome R-HSA-9658195Inferred only
FCGR1A participates in Leishmania parasite growth and survivalPathwayReactome R-HSA-9664433Inferred only
FCGR1A participates in Microglia pathogen phagocytosis pathwayPathwayWikiPathways WP3937Inferred only
FCGR1A participates in Parasitic Infection PathwaysPathwayReactome R-HSA-9824443Inferred only
FCGR1A participates in Regulation of actin dynamics for phagocytic cup formationPathwayReactome R-HSA-2029482Inferred only
FCGR1A participates in Role of phospholipids in phagocytosisPathwayReactome R-HSA-2029485Inferred only
FCGR1A regulates positive regulation of phagocytosisBiological processgene ontology P12314|GO:0050766Inferred only
FCGR1A regulates positive regulation of tumor necrosis factor productionBiological processgene ontology P12314|GO:0032760Inferred only

Other names

9 names

Resolves to: FCGR1A

Also called: CD antigen CD64Fc-gamma RIFc-gamma RIAFCG1FcgammaRIaFCGR1FcRIIGFR1IgG Fc receptor I

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