Proteins/UNIPROT:Q6X9E4

FBXW12

ProteinUNIPROT:Q6X9E4

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes degradation of interleukin-22 receptor subunit IL22RA1 in resting and IL22-stimulated conditions by facilitating its ubiquitination. Functions as a cell growth suppressor..

Function from UniProtKB (Q6X9E4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 2 reference databases · Subject: FBXW12 · Sources: Hetionet, Reactome

Order

FBXW12 covaries with STPG2ProteinHetionet hetionet:covaries:285231-285555Inferred only
FBXW12 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
FBXW12 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
FBXW12 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
FBXW12 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
FBXW12 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
FBXW12 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
FBXW12 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Other names

5 names

Resolves to: FBXW12

Also called: F-box and WD-40 domain-containing protein 12F-box only protein 35FBW12FBXO12FBXO35

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