Proteins/UNIPROT:Q5XX13

FBXW10

ProteinUNIPROT:Q5XX13

Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1..

Function from UniProtKB (Q5XX13), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 2 reference databases · Subject: FBXW10 · Sources: Hetionet, Reactome

Order

AFF3 covaries with FBXW10ProteinHetionet hetionet:covaries:10517-3899Inferred only
FBXW10 covaries with AQRProteinHetionet hetionet:covaries:10517-9716Inferred only
ENPP3 covaries with FBXW10ProteinHetionet hetionet:covaries:10517-5169Inferred only
LAMA1 covaries with FBXW10ProteinHetionet hetionet:covaries:10517-284217Inferred only
MAN1A1 covaries with FBXW10ProteinHetionet hetionet:covaries:10517-4121Inferred only
FBXW10 covaries with OR10W1ProteinHetionet hetionet:covaries:10517-81341Inferred only
PRR11 covaries with FBXW10ProteinHetionet hetionet:covaries:10517-55771Inferred only
PTP4A1 covaries with FBXW10ProteinHetionet hetionet:covaries:10517-7803Inferred only
RHOBTB3 covaries with FBXW10ProteinHetionet hetionet:covaries:10517-22836Inferred only
THEMIS covaries with FBXW10ProteinHetionet hetionet:covaries:10517-387357Inferred only
FBXW10 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
FBXW10 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only

Show the remaining 8

FBXW10 participates in Association of TriC/CCT with target proteins during biosynthesisPathwayReactome R-HSA-390471Inferred only
FBXW10 participates in Chaperonin-mediated protein foldingPathwayReactome R-HSA-390466Inferred only
FBXW10 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
FBXW10 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
FBXW10 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
FBXW10 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
FBXW10 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
FBXW10 participates in Protein foldingPathwayReactome R-HSA-391251Inferred only

Other names

2 names

Resolves to: FBXW10

Also called: F-box and WD-40 domain-containing protein 10Ubiquitin ligase-specificity factor

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