Proteins/UNIPROT:Q9H4M3

FBXO44

ProteinUNIPROT:Q9H4M3

Substrate-recognition component of two distinct E3 ligase complexes, the SKP1-CUL1-FBXO44 complex and the CUL4B-DDB1-FBXO44 complex. The complex SCF(FBXO44) complex ubiquitinates and mediates BRCA1 degradation. In association with cullin 4B/CUL4B and DDB1, mediates the ubiquitination of RGS2 leading to its degradation. Additionally, regulates the pregnane X receptor/NR1I2 protein level by ubiquitination and degradation..

Function from UniProtKB (Q9H4M3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 2 reference databases · Subject: FBXO44 · Sources: Hetionet, Reactome

Order

BARD1 interacts with FBXO44ProteinHetionet hetionet:interacts:580-93611Inferred only
COPS5 interacts with FBXO44ProteinHetionet hetionet:interacts:10987-93611Inferred only
COPS6 interacts with FBXO44ProteinHetionet hetionet:interacts:10980-93611Inferred only
CUL1 interacts with FBXO44ProteinHetionet hetionet:interacts:8454-93611Inferred only
SKP1 interacts with FBXO44ProteinHetionet hetionet:interacts:6500-93611Inferred only
UBC interacts with FBXO44ProteinHetionet hetionet:interacts:7316-93611Inferred only
FBXO44 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
FBXO44 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
FBXO44 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
FBXO44 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
FBXO44 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
FBXO44 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only

Show the remaining 1

FBXO44 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Other names

7 names

Resolves to: FBXO44

Also called: F-box protein FBX30F-box/G-domain protein 3FBG3FBX30FBX44FBX6AFBXO6A

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