Proteins/UNIPROT:Q5HYJ3

FAM76B

ProteinUNIPROT:Q5HYJ3

Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm. Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling..

Function from UniProtKB (Q5HYJ3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 2 reference databases · Subject: FAM76B · Sources: gene ontology, Hetionet

Order

FAM76B covaries with ACTL8ProteinHetionet hetionet:covaries:143684-81569Inferred only
ARF6 covaries with FAM76BProteinHetionet hetionet:covaries:143684-382Inferred only
KCNK5 covaries with FAM76BProteinHetionet hetionet:covaries:143684-8645Inferred only
MED21 covaries with FAM76BProteinHetionet hetionet:covaries:143684-9412Inferred only
SGK3 covaries with FAM76BProteinHetionet hetionet:covaries:143684-23678Inferred only
KRTAP4-12 interacts with FAM76BProteinHetionet hetionet:interacts:143684-83755Inferred only
SRPK1 interacts with FAM76BProteinHetionet hetionet:interacts:143684-6732Inferred only
SRPK2 interacts with FAM76BProteinHetionet hetionet:interacts:143684-6733Inferred only
FAM76B regulates negative regulation of inflammatory responseBiological processgene ontology Q5HYJ3|GO:0050728Inferred only
FAM76B regulates negative regulation of macrophage activationBiological processgene ontology Q5HYJ3|GO:0043031Inferred only
FAM76B regulates negative regulation of protein export from nucleusBiological processgene ontology Q5HYJ3|GO:0046826Inferred only

Other names

1 name

Resolves to: FAM76B

Also called: Protein FAM76B

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