Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P00740

F9

Protein·UNIPROT:P00740

Open in the graph

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa..

Function from UniProtKB (P00740), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

6 rows

hemophilia B has a germline basis in F9DiseaseGenCC HGNC:3551|MONDO:0010604Inferred only
mild hemophilia B has a germline basis in F9DiseaseGenCC HGNC:3551|MONDO:0015717Inferred only
moderately severe hemophilia B has a germline basis in F9DiseaseGenCC HGNC:3551|MONDO:0015716Inferred only
severe hemophilia B has a germline basis in F9DiseaseGenCC HGNC:3551|MONDO:0015715Inferred only
symptomatic form of hemophilia B in female carriers has a germline basis in F9DiseaseGenCC HGNC:3551|MONDO:0015788Inferred only
thrombophilia, X-linked, due to factor 9 defect has a germline basis in F9DiseaseGenCC HGNC:3551|MONDO:0010432Inferred only

Statements

34 statements

34 statements · 3 reference databases · Subject: F9 · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

F7 interacts with F9ProteinHetionet hetionet:interacts:2155-2158Inferred only
F8 interacts with F9ProteinHetionet hetionet:interacts:2157-2158Inferred only
F9 interacts with GGCXProteinHetionet hetionet:interacts:2158-2677Inferred only
F9 interacts with LRP1ProteinHetionet hetionet:interacts:2158-4035Inferred only
SERPINC1 interacts with F9ProteinHetionet hetionet:interacts:2158-462Inferred only
F9 participates in Amplification and propagation of coagulation cascadePathwayReactome R-HSA-9769743Inferred only
F9 participates in Blood clotting cascadePathwayWikiPathways WP272Inferred only
F9 participates in Coagulation pathwayPathwayReactome R-HSA-9769740Inferred only
F9 participates in Complement and coagulation cascadesPathwayWikiPathways WP558Inferred only
F9 participates in Defective cofactor function of FVIIIa variantPathwayReactome R-HSA-9672396Inferred only
F9 participates in Defective F9 activationPathwayReactome R-HSA-9673221Inferred only
F9 participates in Defective F9 secretionPathwayReactome R-HSA-9673218Inferred only

Show the remaining 22

F9 participates in Defective F9 variant does not activate FXPathwayReactome R-HSA-9673202Inferred only
F9 participates in Defective factor IX causes hemophilia BPathwayReactome R-HSA-9668250Inferred only
F9 participates in Defective factor IX causes thrombophiliaPathwayReactome R-HSA-9672383Inferred only
F9 participates in Defective factor VIII causes hemophilia APathwayReactome R-HSA-9662001Inferred only
F9 participates in Defective gamma-carboxylation of F9PathwayReactome R-HSA-9673240Inferred only
F9 participates in Defects of Coagulation cascadePathwayReactome R-HSA-9769726Inferred only
F9 participates in Dengue 2 interactions with complement and coagulation cascadesPathwayWikiPathways WP3896Inferred only
F9 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
F9 participates in Diseases of hemostasisPathwayReactome R-HSA-9671793Inferred only
F9 participates in FXIIa, PKa-dependent activation of coagulation pathwayPathwayReactome R-HSA-9935598Inferred only
F9 participates in Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activationPathwayReactome R-HSA-163841Inferred only
F9 participates in Gamma-carboxylation of protein precursorsPathwayReactome R-HSA-159740Inferred only
F9 participates in Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsPathwayReactome R-HSA-159854Inferred only
F9 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
F9 participates in Initiation of coagulation cascadePathwayReactome R-HSA-9769735Inferred only
F9 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
F9 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
F9 participates in Protein hydroxylationPathwayReactome R-HSA-9629569Inferred only
F9 participates in Regulation of clotting cascadePathwayReactome R-HSA-9769739Inferred only
F9 participates in Removal of aminoterminal propeptides from gamma-carboxylated proteinsPathwayReactome R-HSA-159782Inferred only
F9 participates in Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusPathwayReactome R-HSA-159763Inferred only
F9 participates in Vitamin K metabolism and activation of dependent proteinsPathwayWikiPathways WP5186Inferred only

Other names

4 names

Resolves to: F9

Also called: [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]Christmas factorPlasma thromboplastin componentPTC

← Every protein Find it in the graph →