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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q05925

EN1

Protein·UNIPROT:Q05925

Open in the graph

Required for proper formation of the apical ectodermal ridge and correct dorsal-ventral patterning in the limb..

Function from UniProtKB (Q05925), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

EN1-related dorsoventral syndrome has a germline basis in EN1DiseaseGenCC HGNC:3342|MONDO:1040032Inferred only

Statements

9 statements

9 statements · 3 reference databases · Subject: EN1 · Sources: gene ontology, Hetionet, WikiPathways

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EGR1 interacts with EN1ProteinHetionet hetionet:interacts:1958-2019Inferred only
EN1 interacts with JUNProteinHetionet hetionet:interacts:2019-3725Inferred only
EN1 interacts with PAX6ProteinHetionet hetionet:interacts:2019-5080Inferred only
EN1 interacts with TLE1ProteinHetionet hetionet:interacts:2019-7088Inferred only
EN1 participates in Dopaminergic neurogenesisPathwayWikiPathways WP2855Inferred only
EN1 participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
EN1 regulates negative regulation of neuron apoptotic processBiological processgene ontology Q05925|GO:0043524Inferred only
EN1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q05925|GO:0000122Inferred only
EN1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q05925|GO:0006357Inferred only

Other names

2 names

Resolves to: EN1

Also called: Homeobox protein en-1Hu-En-1

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