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Proteins/UNIPROT:Q9HC35

EML4

Protein·UNIPROT:Q9HC35

Open in the graph

Essential for the formation and stability of microtubules (MTs). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs. Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression..

Function from UniProtKB (Q9HC35), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

19 statements

19 statements · 3 reference databases · Subject: EML4 · Sources: Hetionet, Reactome, WikiPathways

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ARIH2 interacts with EML4ProteinHetionet hetionet:interacts:10425-27436Inferred only
ARL4D interacts with EML4ProteinHetionet hetionet:interacts:27436-379Inferred only
UBC interacts with EML4ProteinHetionet hetionet:interacts:27436-7316Inferred only
EML4 participates in ALK mutants bind TKIsPathwayReactome R-HSA-9700645Inferred only
EML4 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
EML4 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
EML4 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
EML4 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
EML4 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
EML4 participates in EML4 and NUDC in mitotic spindle formationPathwayReactome R-HSA-9648025Inferred only
EML4 participates in M PhasePathwayReactome R-HSA-68886Inferred only
EML4 participates in Mitotic PrometaphasePathwayReactome R-HSA-68877Inferred only

Show the remaining 7

EML4 participates in Non small cell lung cancerPathwayWikiPathways WP4255Inferred only
EML4 participates in Signaling by ALK fusions and activated point mutantsPathwayReactome R-HSA-9725370Inferred only
EML4 participates in Signaling by ALK in cancerPathwayReactome R-HSA-9700206Inferred only
ATP5MG decreases the expression of EML4ProteinHetionet hetionet:regulates:10632-27436Inferred only
KHDRBS1 decreases the expression of EML4ProteinHetionet hetionet:regulates:10657-27436Inferred only
OXA1L decreases the expression of EML4ProteinHetionet hetionet:regulates:5018-27436Inferred only
PDHX decreases the expression of EML4ProteinHetionet hetionet:regulates:8050-27436Inferred only

Other names

5 names

Resolves to: EML4

Also called: C2orf2EMAP-4EMAPL4Restrictedly overexpressed proliferation-associated proteinRopp 120

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