Proteins/UNIPROT:Q8N140

EID3

ProteinUNIPROT:Q8N140

Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components..

Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors..

Function from UniProtKB (Q8N140), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 4 reference databases · Subject: EID3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

PTOV1 covaries with EID3ProteinHetionet hetionet:covaries:493861-53635Inferred only
PWWP3B covaries with EID3ProteinHetionet hetionet:covaries:139221-493861Inferred only
APPBP2 interacts with EID3ProteinHetionet hetionet:interacts:10513-493861Inferred only
EID2 interacts with EID3ProteinHetionet hetionet:interacts:163126-493861Inferred only
HDAC1 interacts with EID3ProteinHetionet hetionet:interacts:3065-493861Inferred only
NSMCE3 interacts with EID3ProteinHetionet hetionet:interacts:493861-56160Inferred only
UBD interacts with EID3ProteinHetionet hetionet:interacts:10537-493861Inferred only
EID3 participates in 15q11q13 copy number variationPathwayWikiPathways WP5407Inferred only
EID3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
EID3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
EID3 participates in SUMO E3 ligases SUMOylate target proteinsPathwayReactome R-HSA-3108232Inferred only
EID3 participates in SUMOylationPathwayReactome R-HSA-2990846Inferred only

Show the remaining 2

EID3 participates in SUMOylation of DNA damage response and repair proteinsPathwayReactome R-HSA-3108214Inferred only
EID3 regulates regulation of telomere maintenanceBiological processgene ontology Q8N140|GO:0032204Inferred only

Other names

6 names

Resolves to: EID3

Also called: E1A-like inhibitor of differentiation 3EID-1-like inhibitor of differentiation 3EID-3Non-SMC element 4 homolog BNon-structural maintenance of chromosomes element 4 homolog BNS4EB

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