Proteins/UNIPROT:P52798

EFNA4

ProteinUNIPROT:P52798

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

Function from UniProtKB (P52798), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: EFNA4 · Sources: Hetionet, Reactome, WikiPathways

Order

EFNA4 interacts with EPHA2ProteinHetionet hetionet:interacts:1945-1969Inferred only
EFNA4 interacts with EPHA3ProteinHetionet hetionet:interacts:1945-2042Inferred only
EFNA4 interacts with EPHA4ProteinHetionet hetionet:interacts:1945-2043Inferred only
EFNA4 interacts with EPHA5ProteinHetionet hetionet:interacts:1945-2044Inferred only
EFNA4 interacts with EPHA6ProteinHetionet hetionet:interacts:1945-285220Inferred only
EFNA4 interacts with EPHA7ProteinHetionet hetionet:interacts:1945-2045Inferred only
EFNA4 interacts with EPHA8ProteinHetionet hetionet:interacts:1945-2046Inferred only
EFNA4 interacts with MAP2K4ProteinHetionet hetionet:interacts:1945-6416Inferred only
EFNA4 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
EFNA4 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
EFNA4 participates in EPH-ephrin mediated repulsion of cellsPathwayReactome R-HSA-3928665Inferred only
EFNA4 participates in EPH-Ephrin signalingPathwayReactome R-HSA-2682334Inferred only

Show the remaining 7

EFNA4 participates in EPHA-mediated growth cone collapsePathwayReactome R-HSA-3928663Inferred only
EFNA4 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
EFNA4 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
EFNA4 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
EFNA4 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
RPS6KL1 increases the expression of EFNA4ProteinHetionet hetionet:regulates:83694-1945Inferred only
VRK2 increases the expression of EFNA4ProteinHetionet hetionet:regulates:7444-1945Inferred only

Other names

4 names

Resolves to: EFNA4

Also called: EPH-related receptor tyrosine kinase ligand 4EPLG4LERK-4LERK4

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