Proteins/UNIPROT:Q9HAK2

EBF2

ProteinUNIPROT:Q9HAK2

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)..

Function from UniProtKB (Q9HAK2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 2 reference databases · Subject: EBF2 · Sources: gene ontology, Reactome

Order

EBF2 participates in AdipogenesisPathwayReactome R-HSA-9843745Inferred only
EBF2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
EBF2 participates in Transcriptional regulation of brown and beige adipocyte differentiationPathwayReactome R-HSA-9843743Inferred only
EBF2 participates in Transcriptional regulation of brown and beige adipocyte differentiation by EBF2PathwayReactome R-HSA-9844594Inferred only
EBF2 regulates positive regulation of cold-induced thermogenesisBiological processgene ontology Q9HAK2|GO:0120162Inferred only
EBF2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9HAK2|GO:0006357Inferred only

Other names

3 names

Resolves to: EBF2

Also called: COE2Early B-cell factor 2EBF-2

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