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Proteins/UNIPROT:Q96EX3
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone..
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation..
Function from UniProtKB (Q96EX3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
21 statements
21 statements · 3 reference databases · Subject: DYNC2I2 · Sources: Hetionet, Reactome, WikiPathways
3 names
Resolves to: DYNC2I2