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Proteins/UNIPROT:Q96MC2

DRC1

Protein·UNIPROT:Q96MC2

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Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules..

Function from UniProtKB (Q96MC2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

primary ciliary dyskinesia has a germline basis in DRC1DiseaseGenCC HGNC:24245|MONDO:0016575Inferred only
primary ciliary dyskinesia 21 has a germline basis in DRC1DiseaseGenCC HGNC:24245|MONDO:0014123Inferred only

Statements

5 statements

5 statements · 3 reference databases · Subject: DRC1 · Sources: gene ontology, Hetionet, WikiPathways

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DRC1 covaries with GARIN5BProteinHetionet hetionet:covaries:284418-92749Inferred only
DRC1 covaries with LYRM9ProteinHetionet hetionet:covaries:201229-92749Inferred only
DRC1 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
DRC1 participates in Smith Magenis and Potocki Lupski syndrome copy number variationPathwayWikiPathways WP5381Inferred only
DRC1 regulates regulation of cilium movementBiological processgene ontology Q96MC2|GO:0003352Inferred only

Other names

4 names

Resolves to: DRC1

Also called: C2orf39CCDC164Coiled-coil domain-containing protein 164Dynein regulatory complex protein 1

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