Proteins/UNIPROT:Q9P104

DOK5

ProteinUNIPROT:Q9P104

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

Function from UniProtKB (Q9P104), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 4 reference databases · Subject: DOK5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

DOK5 covaries with HOXD4ProteinHetionet hetionet:covaries:3233-55816Inferred only
NUDT10 covaries with DOK5ProteinHetionet hetionet:covaries:170685-55816Inferred only
DOK5 covaries with PER2ProteinHetionet hetionet:covaries:55816-8864Inferred only
BNIP3L interacts with DOK5ProteinHetionet hetionet:interacts:55816-665Inferred only
CCDC85B interacts with DOK5ProteinHetionet hetionet:interacts:11007-55816Inferred only
EGFR interacts with DOK5ProteinHetionet hetionet:interacts:1956-55816Inferred only
RET interacts with DOK5ProteinHetionet hetionet:interacts:55816-5979Inferred only
DOK5 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
DOK5 participates in Brain derived neurotrophic factor BDNF signalingPathwayWikiPathways WP2380Inferred only
DOK5 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
DOK5 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
DOK5 participates in RET signalingPathwayReactome R-HSA-8853659Inferred only

Show the remaining 1

DOK5 regulates regulation of neurotrophin TRK receptor signaling pathwayBiological processgene ontology Q9P104|GO:0051386Inferred only

Other names

5 names

Resolves to: DOK5

Also called: C20orf180Downstream of tyrosine kinase 5Insulin receptor substrate 6IRS-6IRS6

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