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Proteins/UNIPROT:Q9H7D0

DOCK5

Protein·UNIPROT:Q9H7D0

Open in the graph

Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Together with ELMO1, activates RAC1; the activity is stimulated by RHOG. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen..

Function from UniProtKB (Q9H7D0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

16 statements

16 statements · 4 reference databases · Subject: DOCK5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ATXN1 interacts with DOCK5ProteinHetionet hetionet:interacts:6310-80005Inferred only
DOCK5 participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
DOCK5 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
DOCK5 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
DOCK5 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
DOCK5 participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
DOCK5 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
DOCK5 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
DOCK5 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
DOCK5 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
DOCK5 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
DOCK5 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only

Show the remaining 4

DOCK5 regulates negative regulation of vascular associated smooth muscle contractionBiological processgene ontology Q9H7D0|GO:1904694Inferred only
DOCK5 regulates positive regulation of epithelial cell migrationBiological processgene ontology Q9H7D0|GO:0010634Inferred only
DOCK5 regulates positive regulation of substrate adhesion-dependent cell spreadingBiological processgene ontology Q9H7D0|GO:1900026Inferred only
DOCK5 regulates positive regulation of vascular associated smooth muscle cell migrationBiological processgene ontology Q9H7D0|GO:1904754Inferred only

Other names

1 name

Resolves to: DOCK5

Also called: Dedicator of cytokinesis protein 5

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