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Proteins/UNIPROT:Q8IWF6

DENND6A

Protein·UNIPROT:Q8IWF6

Open in the graph

Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes..

Function from UniProtKB (Q8IWF6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

6 statements

6 statements · 3 reference databases · Subject: DENND6A · Sources: gene ontology, Hetionet, Reactome

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UBC interacts with DENND6AProteinHetionet hetionet:interacts:201627-7316Inferred only
DENND6A participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
DENND6A participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
DENND6A participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
DENND6A participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
DENND6A regulates positive regulation of cell-cell adhesion mediated by cadherinBiological processgene ontology Q8IWF6|GO:2000049Inferred only

Other names

3 names

Resolves to: DENND6A

Also called: DENN domain-containing protein 6AFAM116AProtein DENND6A

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