Proteins/UNIPROT:Q6ZUT9

DENND5B

ProteinUNIPROT:Q6ZUT9

Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form..

Function from UniProtKB (Q6ZUT9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

neurodevelopmental disorder has a germline basis in DENND5BDiseaseGenCC HGNC:28338|MONDO:0700092Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: DENND5B · Sources: gene ontology, Hetionet, Reactome

Order

DENND5B covaries with CUL2ProteinHetionet hetionet:covaries:160518-8453Inferred only
DUSP15 covaries with DENND5BProteinHetionet hetionet:covaries:128853-160518Inferred only
LIAT1 covaries with DENND5BProteinHetionet hetionet:covaries:160518-400566Inferred only
PPP1R18 covaries with DENND5BProteinHetionet hetionet:covaries:160518-170954Inferred only
ZNF227 covaries with DENND5BProteinHetionet hetionet:covaries:160518-7770Inferred only
UBC interacts with DENND5BProteinHetionet hetionet:interacts:160518-7316Inferred only
DENND5B participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
DENND5B participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
DENND5B participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
DENND5B participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
DENND5B regulates positive regulation of triglyceride transportBiological processgene ontology Q6ZUT9|GO:1905885Inferred only

Other names

2 names

Resolves to: DENND5B

Also called: DENN domain-containing protein 5BRab6IP1-like protein

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