Proteins/UNIPROT:Q8TEH3

DENND1A

ProteinUNIPROT:Q8TEH3

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity)..

Function from UniProtKB (Q8TEH3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: DENND1A · Sources: gene ontology, Hetionet, Reactome

Order

DENND1A covaries with CALCOCO1ProteinHetionet hetionet:covaries:57658-57706Inferred only
DENND1A covaries with IFITM1ProteinHetionet hetionet:covaries:57706-8519Inferred only
DENND1A covaries with NISCHProteinHetionet hetionet:covaries:11188-57706Inferred only
DENND1A covaries with NYNRINProteinHetionet hetionet:covaries:57523-57706Inferred only
DENND1A covaries with PCDHB10ProteinHetionet hetionet:covaries:56126-57706Inferred only
DENND1A covaries with PDE3BProteinHetionet hetionet:covaries:5140-57706Inferred only
DENND1A covaries with SNORCProteinHetionet hetionet:covaries:389084-57706Inferred only
DENND1A covaries with TROAPProteinHetionet hetionet:covaries:10024-57706Inferred only
DENND1A covaries with ZNF10ProteinHetionet hetionet:covaries:57706-7556Inferred only
DENND1A covaries with ZNF26ProteinHetionet hetionet:covaries:57706-7574Inferred only
DENND1A covaries with ZNF574ProteinHetionet hetionet:covaries:57706-64763Inferred only
DENND1A participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only

Show the remaining 4

DENND1A participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
DENND1A participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
DENND1A participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
DENND1A regulates regulation of Rab protein signal transductionBiological processgene ontology Q8TEH3|GO:0032483Inferred only

Other names

5 names

Resolves to: DENND1A

Also called: ConnecdennConnecdenn 1FAM31AKIAA1608Protein FAM31A

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